wuttkeheaderbg

WuttkePublications

1.     Lewis KA, Pfaff DA, Earley JN, Altschuler SE, Wuttke DS. (2014) “The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domain.” Nucleic Acids Res. 42(1):475.
link

2.     Rao T, Lubin JW, Armstrong GS, Tucey TM, Lundblad V, Wuttke DS. (2014) "Structure of Est3 reveals a bimodal surface with differential roles in telomere replication." Proc Natl Acad Sci USA 111(1)214.
link

3.     Altschuler SE*, Lewis KA*, and Wuttke DS. (2013) “Practical strategies for the evaluation of high-affinity protein/nucleic acid interactions.” J. Nucleic Acids Invest. 4(1):e3.

4.     Dickey TH, Altschuler SE, Wuttke DS. Single-Stranded DNA-Binding Proteins: Multiple Domains for Multiple Functions. Structure. 2013 Jul 2;21(7):1074-84.
doi: 10.1016/j.str.2013.05.013. PubMed PMID: 23823326.
link

5.     Lubin JW, Rao T, Mandell EK, Wuttke DS, Lundblad V. Dissecting protein function: an efficient protocol for identifying separation-of-function mutations that encode structurally stable proteins. Genetics. 2013 Mar;193(3):715-25.
doi:10.1534/genetics.112.147801. Epub 2013 Jan 10. PubMed PMID: 23307900; PubMed Central PMCID: PMC3583993.

6.     Dickey TH, McKercher MA, Wuttke DS. Nonspecific recognition is achieved in Pot1pC through the use of multiple binding modes. Structure. 2013 Jan 8;21(1):121-32.
doi: 10.1016/j.str.2012.10.015. Epub 2012 Nov 29. PubMed PMID: 23201273; PubMed Central PMCID: PMC3545015.

7.     Altschuler SE, Croy JE, Wuttke DS. A small molecule inhibitor of Pot1 binding to telomeric DNA. Biochemistry. 2012 Oct 9;51(40):7833-45.
doi: 10.1021/bi300365k. Epub 2012 Sep 26. PubMed PMID: 22978652; PubMed Central PMCID: PMC3514547.

8.     Lewis KA, Wuttke DS. Telomerase and telomere-associated proteins: structural insights into mechanism and evolution. Structure. 2012 Jan 11;20(1):28-39.
doi: 10.1016/j.str.2011.10.017. Review. PubMed PMID: 22244753.

9.     Braun LJ, Eldridge AM, Cummiskey J, Arthur KK, Wuttke DS. The role of adjuvant in mediating antigen structure and stability. J Pharm Sci. 2012 Apr;101(4):1391-9.
doi: 10.1002/jps.23039. Epub 2011 Dec 28. PubMed PMID: 22213631.

10.Altschuler SE, Dickey TH, Wuttke DS. Schizosaccharomyces pombe protection of telomeres 1 utilizes alternate binding modes to accommodate different telomeric sequences. Biochemistry. 2011 Sep 6;50(35):7503-13.
doi: 10.1021/bi200826a. Epub 2011 Aug 16. PubMed PMID: 21815629; PubMed Central PMCID: PMC3184176.

11.Mandell EK, Gelinas AD, Wuttke DS, Lundblad V. Sequence-specific binding to telomeric DNA is not a conserved property of the Cdc13 DNA binding domain. Biochemistry. 2011 Jul 26;50(29):6289-91.
doi: 10.1021/bi2005448. Epub 2011 Jun 29. PubMed PMID: 21668015.

12.Alford JR, Fowler AC, Wuttke DS, Kerwin BA, Latypov RF, Carpenter JF, Randolph TW. Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange. J Pharm Sci. 2011 May 5.
doi: 10.1002/jps.22601. [Epub ahead of print] PubMed PMID: 21557223.

13.Lee J, Mandell EK, Rao T, Wuttke DS, Lundblad V. Investigating the role of the Est3 protein in yeast telomere replication. Nucleic Acids Res. 2010 Apr;38(7):2279-90.
doi: 10.1093/nar/gkp1173. Epub 2010 Jan 4. PubMed PMID: 20047960; PubMed Central PMCID: PMC2853109.

14.Gelinas AD, Paschini M, Reyes FE, Héroux A, Batey RT, Lundblad V, Wuttke DS. Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19298-303.
doi: 10.1073/pnas.0909203106. Epub 2009 Nov 2. PubMed PMID: 19884503; PubMed Central PMCID: PMC2780795.

15.Croy JE, Altschuler SE, Grimm NE, Wuttke DS. Nonadditivity in the recognition of single-stranded DNA by the schizosaccharomyces pombe protection of telomeres 1 DNA-binding domain, Pot1-DBD. Biochemistry. 2009 Jul 28;48(29):6864-75.
doi: 10.1021/bi900307x. PubMed PMID: 19518131; PubMed Central PMCID: PMC2756145.

16.Croy JE, Wuttke DS. Insights into the dynamics of specific telomeric single-stranded DNA recognition by Pot1pN. J Mol Biol. 2009 Apr 10;387(4):935-48.
doi: 10.1016/j.jmb.2009.02.016. Epub 2009 Feb 13. PubMed PMID: 19232358.

17.Zappulla DC, Roberts JN, Goodrich KJ, Cech TR, Wuttke DS. Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic Acids Res. 2009 Feb;37(2):354-67.
doi: 10.1093/nar/gkn830. Epub 2008 Nov 29. PubMed PMID: 19043074; PubMed Central PMCID: PMC2632905.

18.Croy JE, Fast JL, Grimm NE, Wuttke DS. Deciphering the mechanism of thermodynamic accommodation of telomeric oligonucleotide sequences by the Schizosaccharomyces pombe protection of telomeres 1 (Pot1pN) protein. Biochemistry. 2008 Apr 15;47(15):4345-58.
doi: 10.1021/bi701778x. Epub 2008 Mar 21. PubMed PMID: 18355038.

19.Theobald DL, Wuttke DS. Accurate structural correlations from maximum likelihood superpositions. PLoS Comput Biol. 2008 Feb;4(2):e43.
doi: 10.1371/journal.pcbi.0040043. PubMed PMID: 18282091; PubMed Central PMCID: PMC2242818.

20.Eldridge AM, Wuttke DS. Probing the mechanism of recognition of ssDNA by the Cdc13-DBD. Nucleic Acids Res. 2008 Mar;36(5):1624-33.
doi: 10.1093/nar/gkn017. Epub 2008 Feb 3. PubMed PMID: 18250086; PubMed Central PMCID: PMC2275150.

21.Alford JR, Kwok SC, Roberts JN, Wuttke DS, Kendrick BS, Carpenter JF, Randolph TW. High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization. J Pharm Sci. 2008 Aug;97(8):3035-50.
PubMed PMID: 17973297.

22.Strauss DM, Wuttke DS. Characterization of protein-protein interactions critical for poliovirus replication: analysis of 3AB and VPg binding to the RNA-dependent RNA polymerase. J Virol. 2007 Jun;81(12):6369-78. Epub 2007 Apr 4.
PubMed PMID: 17409142; PubMed Central PMCID: PMC1900118.

23.Theobald DL, Wuttke DS. Empirical Bayes hierarchical models for regularizing maximum likelihood estimation in the matrix Gaussian Procrustes problem. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18521-7. Epub 2006 Nov 27.
PubMed PMID: 17130458; PubMed Central PMCID: PMC1664551.

24.Croy JE, Wuttke DS. Themes in ssDNA recognition by telomere-end protection proteins. Trends Biochem Sci. 2006 Sep;31(9):516-25.
Epub 2006 Aug 4. Review. PubMed PMID: 16890443.

25.Croy JE, Podell ER, Wuttke DS. A new model for Schizosaccharomyces pombe telomere recognition: the telomeric single-stranded DNA-binding activity of Pot11-389. J Mol Biol. 2006 Aug 4;361(1):80-93. Epub 2006 Jun 19. Erratum in: J Mol Biol. 2006 Oct 6;362(5):1181.
PubMed PMID: 16842820.

26.Theobald DL, Wuttke DS. THESEUS: maximum likelihood superpositioning and analysis of macromolecular structures. Bioinformatics. 2006 Sep 1;22(17):2171-2. Epub 2006 Jun 15.
PubMed PMID: 16777907; PubMed Central PMCID: PMC2584349.

27.Eldridge AM, Halsey WA, Wuttke DS. Identification of the determinants for the specific recognition of single-strand telomeric DNA by Cdc13. Biochemistry. 2006 Jan 24;45(3):871-9.
PubMed PMID: 16411763; PubMed Central PMCID: PMC3514546.

28.Theobald DL, Wuttke DS. Divergent evolution within protein superfolds inferred from profile-based phylogenetics. J Mol Biol. 2005 Dec 2;354(3):722-37. Epub 2005 Sep 20.
PubMed PMID: 16266719; PubMed Central PMCID: PMC1769326.

29.Jacobs SA, Podell ER, Wuttke DS, Cech TR. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Sci. 2005 Aug;14(8):2051-8.
PubMed PMID: 16046627; PubMed Central PMCID: PMC2279316.

30.Theobald DL, Wuttke DS. Prediction of multiple tandem OB-fold domains in telomere end-binding proteins Pot1 and Cdc13. Structure. 2004 Oct;12(10):1877-9.
PubMed PMID: 15458635.

31.Mitton-Fry RM, Anderson EM, Theobald DL, Glustrom LW, Wuttke DS. Structural basis for telomeric single-stranded DNA recognition by yeast Cdc13. J Mol Biol. 2004 Apr 23;338(2):241-55.
PubMed PMID: 15066429.

32.Wuttke DS. Targeting the end; the structure of the Ku80 C-terminal domain. Structure. 2004 Mar;12(3):355-6.
PubMed PMID: 15016349.

33.Theobald DL, Cervantes RB, Lundblad V, Wuttke DS. Homology among telomeric end-protection proteins. Structure. 2003 Sep;11(9):1049-50.
PubMed PMID: 12962623.

34.Strauss DM, Glustrom LW, Wuttke DS. Towards an understanding of the poliovirus replication complex: the solution structure of the soluble domain of the poliovirus 3A protein. J Mol Biol. 2003 Jul 4;330(2):225-34.
PubMed PMID: 12823963.

35.Anderson EM, Halsey WA, Wuttke DS. Site-directed mutagenesis reveals the thermodynamic requirements for single-stranded DNA recognition by the telomere-binding protein Cdc13. Biochemistry. 2003 Apr 8;42(13):3751-8.
PubMed PMID: 12667066.

36.Theobald DL, Mitton-Fry RM, Wuttke DS. Nucleic acid recognition by OB-fold proteins. Annu Rev Biophys Biomol Struct. 2003;32:115-33. Epub 2003 Feb 18. Review.
PubMed PMID: 12598368; PubMed Central PMCID: PMC1564333.

37.Ojennus DD, Lehto SE, Wuttke DS. Electrostatic interactions in the reconstitution of an SH2 domain from constituent peptide fragments. Protein Sci. 2003 Jan;12(1):44-55.
PubMed PMID: 12493827; PubMed Central PMCID: PMC2312404.

38.Anderson EM, Halsey WA, Wuttke DS. Delineation of the high-affinity single-stranded telomeric DNA-binding domain of Saccharomyces cerevisiae Cdc13. Nucleic Acids Res. 2002 Oct 1;30(19):4305-13.
PubMed PMID: 12364610; PubMed Central PMCID: PMC140553.

39.Glustrom LW, Mitton-Fry RM, Wuttke DS. Re: 1,1-Dichloro-2,2-bis-(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. J Natl Cancer Inst. 2002 Sep 4;94(17):1337-8; author reply 1338-9.
PubMed PMID: 12208902.

40.Mitton-Fry RM, Wuttke DS. 1H, 13C and 15N resonance assignments of the DNA-binding domain of the essential protein Cdc13 complexed with single-stranded telomeric DNA. J Biomol NMR. 2002 Apr;22(4):379-80.
PubMed PMID: 12018489.

41.Mitton-Fry RM, Anderson EM, Hughes TR, Lundblad V, Wuttke DS. Conserved structure for single-stranded telomeric DNA recognition. Science. 2002 Apr 5;296(5565):145-7. PubMed PMID: 11935027.

42.Ojennus DD, Fleissner MR, Wuttke DS. Reconstitution of a native-like SH2 domain from disordered peptide fragments examined by multidimensional heteronuclear NMR. Protein Sci. 2001 Nov;10(11):2162-75.
PubMed PMID: 11604523; PubMed Central PMCID: PMC2374061.

43.Dahlke Ojennus D, Mitton-Fry RM, Wuttke DS. Induced alignment and measurement of dipolar couplings of an SH2 domain through direct binding with filamentous phage. J Biomol NMR. 1999 Jun;14(2):175-9.
doi: 10.1023/A:1008304332574. PubMed PMID: 21080256.