Dr. Tad H Koch
Department of Chemistry & Biochemistry
University of Colorado at Boulder
Professor Koch and his students and co-workers are investigating aspects of bioorganic chemistry, medicinal chemistry, photochemistry, and free radical chemistry.They are particularly interested in the chemistry of the anthracycline quinone antitumor drugs, Adriamycin (doxorubicin), Epirubicin (epidoxorubicin) and Daunomycin (daunorubicin), relevant to their modes of biological activity and drug development. The research group has studied nucleic acid photochemistry and its application to the elucidation of protein nucleic acid interactions. The synthesis and properties of amino-carboxy-stabilized carbon radicals such as 3,5,5-trimethyl-2-oxomorpholin-3-yl (TM-3) was an earlier area of interest. Descriptions of these projects are expanded as follows.