POSTDOCTORAL SCIENTIST

JOB SUMMARY:

 

We require a highly motivated Postdoctoral Scientist to work on

protein stability & aggregation as it relates to therapeutic protein development. The

current postdoctoral project is designed to understand the fundamental mechanism/s of

protein instability, sub-visible particulate formation and aggregation using variety of

chromatographic, biophysical and biochemical tools.

DUTIES AND RESPONSIBILITIES:

SCIENTIFIC RESPONSIBILITIES:

•

Evaluate physical and biophysical properties of peptides and proteins relevant to

drug development and subsequently communicate the interpretation and

implication of results to clients.

•

Develop analytical methods and characterize product variants

•

Execute and oversee specialized analytical testing and generation of technical

documents

•

Maintain a strong awareness of current scientific literature, particularly in the area

of protein characterization, and actively apply new concepts as appropriate.

•

Develop and evaluate new cutting-edge technologies for protein product

understanding, especially product heterogeneity and impact on safety and

efficacy.

•

Design experiments to develop pre-clinical and clinical formulations of drug

candidates to support drug discovery and development.

•

Design experiments to determine the stability in prototype clinical formulations,

to detect and identify the decomposition products, and to achieve formulations

with acceptable shelf-life.

•

Perform laboratory experiments related to the above.

•

Create presentations for outside scientific meetings and conferences to showcase

Wolfe Laboratories’ scientific leadership in the field of protein analysis and

characterization.

CLIENT INTERACTION RESPONSIBILITIES:

•

Interface with clients to develop an in-depth understanding of client objectives

and define solutions to meet their program requirements

•

Develop compelling approaches and solutions to address client needs

•

Write persuasive proposals for the projects

•

Regularly interact with clients to keep them abreast of project progress

•

Write and review interim and final reports.

REQUIRED BACKGROUND AND EXPERIENCE:

•

Ph.D. in Biochemistry, Biophysics, Chemistry or closely related disciplines

•

In depth experience in the area of protein biophysical chemistry of proteins

involving structure-folding-stability relationships. This includes purification,

stability, kinetics and thermodynamics of folding of monomeric proteins,

particularly as they relate to the pre-formulation and formulation development of

new drugs

•

Hands-on experience with chromatographic method development as well as

techniques used for biophysical characterization of biopharmaceutical products

such as calorimetry, spectroscopy, higher order structure analysis, protein mass

spectroscopy, CE, HPLC, ELISA, and carbohydrate analysis.

•

A demonstrated drive to apply technical knowledge to developing drug

formulations

•

Established track record of significant contributions as an individual technical

expert

•

Outstanding written and oral communication skills as well as polished and

persuasive client presentation skills

ADDITIONAL DESIRABLE BACKGROUND:

•

Post doctoral experience in analytical biochemistry or closely related discipline.

•

Good understanding of excipient and ligand interaction with proteins

•

Evaluation of thermodynamic and kinetic models

WHERE THIS JOB COULD LEAD:

At Wolfe Laboratories Inc., we pride ourselves on retaining and growing our team

members, and ensuring they are developing to their full potential. This position can

provide many different avenues for advancement, including:

•

Training towards becoming a Project Manager

•

Leader of an innovative business line

•

Become a Lead Technical Researcher (if successful in winning funding)

•

Managing a team of Postdoctoral employees

Interested candidates are requested to email a copy of their resume with a cover letter

including salary history to:

This email address is being protected from spambots. You need JavaScript enabled to view it.

Wolfe Laboratories, Inc. (WLI), located in Watertown, MA, is a premier contract research

organization that provides integrated early drug development solutions to the biopharmaceutical

industry. Wolfe Laboratories is an essential element of the drug development ecosystem,

recognized by global and virtual biopharmaceutical companies as a science-driven organization

whose mission is to provide outstanding discovery and development services tailored to its

clients’ needs for rational formulation development. Wolfe Laboratories integrates the critical

path components of early development to ensure that programs advance while meeting rigorous

scientific demands with flexibility to address dynamic challenges and aggressive timelines.

Wolfe Laboratories’ vision is to improve human health, and we continue to strive towards that

goal by embracing our core values of integrity, excellence and teamwork. The company has a

high percentage of repeat clients, which is a testament to its long-term commitment of continual

investment in its capabilities to meet biopharma’s growing demand for high quality, integrated

early development services.

We have a steady 12-year track record of growth, success and profitability.

For more information visit us at:

www.wolfelabs.com

.

Wolfe Laboratories, Inc is an Equal Employment Opportunity employer.

Postdoctoral Position in Advanced Materials/Heterogeneous Catalysis/Monolithic Reactors
Departments of Chemistry and Chemical and Biological Engineering

The University of Alabama

Our dynamic interdisciplinary faculty team of Ryan Hartman (Chemical and Biological
Engineering), Martin Bakker (Chemistry) and Kevin Shaughnessy (Chemistry) is combining
Materials Chemistry, Heterogeneous Catalysis and Monolithic Reactors, and has a Post-doctoral
position open for an outstanding candidate with experience in one or more of the following
areas: heterogeneous catalysis, sol-gel synthesis, synthesis of self-organizing materials and
continuous reactors. The project will involve scale up of various sol-gel based methods for
making hierarchically porous catalysts, the incorporation of these materials into a flow reactor,
and studying the efficiency of the catalysis under process conditions. More details concerning
the project can be found by contacting Dr. Ryan Hartman ( This email address is being protected from spambots. You need JavaScript enabled to view it. , 205-348-1696)
Dr. Bakker ( This email address is being protected from spambots. You need JavaScript enabled to view it. , 205-348-9116) or Dr. Shaughnessy ( This email address is being protected from spambots. You need JavaScript enabled to view it. ,
205-348-4435).

The position is available starting June 1 2013 and is for a year, renewable by mutual agreement
for a second year. Application is made online at http://faculty jobs.ua.edu/postings/31562

The University of Alabama is an Equal Opportunity Affirmative Action Employer. Women and minorities are encouraged to apply.

Quality Systems Supervisor

An opportunity exists for an exceptional individual in the area of Quality Systems, focusing on
the management of Quality Control and Quality Assurance. The QS Supervisor will work under the
guidance of the Associate Director of Quality to implement and maintain Quality Systems supporting
the Wolfe Laboratories GLP/GMP/GCP analytical testing and characterization program. The individual
must be highly motivated toward increasing level of responsibility and leadership. The individual must be
willing to receive a combination of on the job and outside training on GLP/GMP/GCP operations.

Responsibilities include:
• Help to maintain and grow all Quality Systems including, but not limited to the
management of:
• Internal audits
• Vendor audits
• Training
• Documentation
• Laboratory controls
• Non-conformances and CAPA
• Ensure compliance with GLP, GMP, and GCP regulations and industry standards as they
relate to Wolfe Laboratories activities
• Provide Quality Assurance oversight for GLP, GMP, and GCP-related activities
• Manage Quality Assurance review of analytical test results, investigations, reports and
protocols for GLP, GMP, and GCP projects
• Manage internal and external audits
• Lead Quality Assurance investigations of non-conformances by analyzing data,
interpreting results and recommending appropriate corrective actions to area managers
• Contribute to the efficiency of Quality Processes by identifying and suggesting
improvements and eliminating non-value added work
• Contribute to writing of proposals or technical agreements for GLP/GMP/GCP projects

Desired Background and Experience:
The successful candidate will hold a Master’s or Ph.D. degree in a science-related field, with 1–3 years of
experience in an equivalent role. Previous laboratory experience required: experience in manufacturing
operations for pharmaceutical/biopharmaceutical or drug development organizations in activities
supporting GMP or GLP functions preferred. Ability to apply established principles, theories and
concepts in areas of laboratory operations. Can propose, design and implement solutions to solve or
prevent problems that have a negative impact on quality of executed work or on compliance with Wolfe
Laboratories Quality Systems and GLP/GMP/GCP regulations. Familiarity with regulatory guidance
documents is highly desirable.

Good communication and interpersonal skills are essential for this position, as it requires working with
both internal and external clients, vendors and suppliers. Prior experience delivering trainings is also
helpful.

Interested candidates are requested to email a copy of their resume with a cover letter including
salary history to: This email address is being protected from spambots. You need JavaScript enabled to view it. .

Wolfe Laboratories, Inc. (WLI), located in Watertown, MA, is a premier contract research
organization that provides integrated early drug development solutions to the biopharmaceutical
industry. Wolfe Laboratories is an essential element of the drug development ecosystem,
recognized by global and virtual biopharmaceutical companies as a science-driven organization
whose mission is to provide outstanding discovery and development services tailored to its
clients’ needs for rational formulation development. Wolfe Laboratories integrates the critical
path components of early development to ensure that programs advance while meeting rigorous
scientific demands with flexibility to address dynamic challenges and aggressive timelines.
Wolfe Laboratories’ vision is to improve human health, and we continue to strive towards that
goal by embracing our core values of integrity, excellence and teamwork. The company has a
high percentage of repeat clients, which is a testament to its long-term commitment of continual
investment in its capabilities to meet biopharma’s growing demand for high quality, integrated
early development services.

We have a steady 12-year track record of growth, success and profitability.

For more information visit us at: www.wolfelabs.com.
Wolfe Laboratories, Inc is an Equal Employment Opportunity employer.

POSTDOCTORAL SCIENTIST

JOB SUMMARY: We require a highly motivated Postdoctoral Scientist to work on
protein stability & aggregation as it relates to therapeutic protein development. The
current postdoctoral project is designed to understand the fundamental mechanism/s of
protein instability, sub-visible particulate formation and aggregation using variety of
chromatographic, biophysical and biochemical tools.

DUTIES AND RESPONSIBILITIES:
SCIENTIFIC RESPONSIBILITIES:
• Evaluate physical and biophysical properties of peptides and proteins relevant to
drug development and subsequently communicate the interpretation and
implication of results to clients.
• Develop analytical methods and characterize product variants
• Execute and oversee specialized analytical testing and generation of technical
documents
• Maintain a strong awareness of current scientific literature, particularly in the area
of protein characterization, and actively apply new concepts as appropriate.
• Develop and evaluate new cutting-edge technologies for protein product
understanding, especially product heterogeneity and impact on safety and
efficacy.
• Design experiments to develop pre-clinical and clinical formulations of drug
candidates to support drug discovery and development.
• Design experiments to determine the stability in prototype clinical formulations,
to detect and identify the decomposition products, and to achieve formulations
with acceptable shelf-life.
• Perform laboratory experiments related to the above.
• Create presentations for outside scientific meetings and conferences to showcase
Wolfe Laboratories’ scientific leadership in the field of protein analysis and
characterization.

CLIENT INTERACTION RESPONSIBILITIES:
• Interface with clients to develop an in-depth understanding of client objectives
and define solutions to meet their program requirements
• Develop compelling approaches and solutions to address client needs
• Write persuasive proposals for the projects
• Regularly interact with clients to keep them abreast of project progress
• Write and review interim and final reports.
REQUIRED BACKGROUND AND EXPERIENCE:
• Ph.D. in Biochemistry, Biophysics, Chemistry or closely related disciplines
• In depth experience in the area of protein biophysical chemistry of proteins
involving structure-folding-stability relationships. This includes purification,
stability, kinetics and thermodynamics of folding of monomeric proteins,
particularly as they relate to the pre-formulation and formulation development of
new drugs
• Hands-on experience with chromatographic method development as well as
techniques used for biophysical characterization of biopharmaceutical products
such as calorimetry, spectroscopy, higher order structure analysis, protein mass
spectroscopy, CE, HPLC, ELISA, and carbohydrate analysis.
• A demonstrated drive to apply technical knowledge to developing drug
formulations
• Established track record of significant contributions as an individual technical
expert
• Outstanding written and oral communication skills as well as polished and
persuasive client presentation skills
ADDITIONAL DESIRABLE BACKGROUND:
• Post doctoral experience in analytical biochemistry or closely related discipline.
• Good understanding of excipient and ligand interaction with proteins
• Evaluation of thermodynamic and kinetic models

Interested candidates are requested to email a copy of their resume with a cover letter
including salary history to: This email address is being protected from spambots. You need JavaScript enabled to view it.

Wolfe Laboratories, Inc. (WLI), located in Watertown, MA, is a premier contract research
organization that provides integrated early drug development solutions to the biopharmaceutical
industry. Wolfe Laboratories is an essential element of the drug development ecosystem,
recognized by global and virtual biopharmaceutical companies as a science-driven organization
whose mission is to provide outstanding discovery and development services tailored to its
clients’ needs for rational formulation development. Wolfe Laboratories integrates the critical
path components of early development to ensure that programs advance while meeting rigorous
scientific demands with flexibility to address dynamic challenges and aggressive timelines.
Wolfe Laboratories’ vision is to improve human health, and we continue to strive towards that
goal by embracing our core values of integrity, excellence and teamwork. The company has a
high percentage of repeat clients, which is a testament to its long-term commitment of continual
investment in its capabilities to meet biopharma’s growing demand for high quality, integrated
early development services.

We have a steady 12-year track record of growth, success and profitability.

For more information visit us at: www.wolfelabs.com.
Wolfe Laboratories, Inc is an Equal Employment Opportunity employer.